Journal Ref: Neth J Med. 2015 May;73(4):147-54. Abstract: This review article describes the epidemiology, clinical presentation, diagnostic workup and treatment options in adult non-cystic fibrosis (non-CF) bronchiectasis (widening of mainly small and medium-sized bronchi as seen on chest computed tomography …
Journal Ref: Biomed Res Int. 2015;2015:197950. doi: 10.1155/2015/197950. Epub 2015 May 27. Review Abstract: During the past decades, a growing interest has been raised in evaluating nontuberculous mycobacteria (NTM) in patients with noncystic fibrosis bronchiectasis (NCFBE). This paper reviews several …
Journal Ref: Harefuah. 2015 Jun;154(6):356-61, 406, 405. Abstract: Bronchiectasis is a suppurative lung disease characterized by wide and distorted bronchi, with daily cough and sputum production punctuated by infectious exacerbations. Etiologies are diverse, and treatment is multidisciplinary, consisting of lung …
Secreted mucins play a key role in antibacterial defence in the airway, but have not previously been characterized in non-cystic fibrosis (CF) bronchiectasis patients. We aim to investigate the relationship between secreted mucins levels and the presence of bacterial colonization …
Journal Ref: BMC Health Serv Res. 2015 Aug 22;15:342. doi: 10.1186/s12913-015-1004-z. Abstract: Low patient adherence to treatment is associated with poorer health outcomes in bronchiectasis. We sought to use the Theoretical Domains Framework (TDF) (a framework derived from 33 psychological …
Journal Ref: Arch Bronconeumol. 2018 Feb;54(2):59-60. doi: 10.1016/j.arbres.2017.06.022. Epub 2017 Aug 1. English, Spanish. No abstract available.
Rationale: Chronic infection with Pseudomonas aeruginosa is associated with an increased exacerbation frequency, a more rapid decline in lung function, and increased mortality in patients with bronchiectasis. Objectives: To perform a randomized placebo-controlled study assessing the efficacy and safety of …
In bronchiectasis there is a need for improved markers of lung function to determine disease severity and response to therapy. OBJECTIVES: To assess whether the lung clearance index is a repeatable and more sensitive indicator of computed tomography (CT) scan …
Reliable markers of disease progression or stability to assist in management decisions are lacking in patients with non-cystic fibrosis bronchiectasis and Mycobacterium avium complex (MAC) infection. METHODS: Data from 52 adults with non-cystic fibrosis bronchiectasis and coexisting MAC infection managed …
Bronchiectasis is characterised by chronic cough, sputum production, and recurrent chest infections. Pathogenesis is poorly understood, but excess neutrophilic airway inflammation is seen. Accumulating evidence suggests that statins have pleiotropic effects; therefore, these drugs could be a potential anti-inflammatory treatment …
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